STRUCTURE

Depending on how complex has the characteristics of a sorbent, it's therapeutic properties manifest as enterosorbent. Analyzing the proposed regulations and clinical practice requirements enterosorbent, there are a set of properties, as inherent to «ideal» enterosorbent:
1. complete safety and non-toxic.
2. high biocompatibility with tissues, blood and other body biosubstratami.
3. nepovrezhdayuschee effect on the mucous membranes of the oral cavity, esophagus, gastrointestinal tract.
4. selective sorption srednemolekulyarnyh toxic metabolites.
5. high adsorption capacity.
Based on the need to ensure full compliance with the most complex properties characteristic of «ideal» enterosorbent were carried out systematic research synthesis, structure and physico-chemical properties of a new porous silicon sorbents. The biggest match of the above properties is set to enterosgelya, which may be in the form of gelevidnoy or after the dehydration (drying) transition in solid-state kserogel.

velichenie It provided electron microscope (h20000) allows to observe a porous structure enterosgelya.

< STRONG> Volumetric - globular structure enterosgelya (within the allocated time for).
chemical structure Enterosgel is spatially sew silicon matrix, resembling a sponge, the size of which has been chosen for the sorption predominantly srednemolekulyarnyh substances.

Skeleton gel consists of Globul, the pores represent empty spaces (gaps) between the globule. Pore size and shape are determined by the diameter Globul their mutual coordination and the density of their packing. On the surface of globules are organic radicals, SN3 neskondensirovannyh and a small amount of hydroxyl end groups of-OH.
Polisiloksanovoy porous structure of the matrix is characterized by a specific surface of 150-250 m2/g and the effective radius of pores over 100 nm. Structure and properties of globular porous matrix determine preferential binding substances in the range of molecular masses from 70 to 1000 Dalton.

; Sorption ability Enterosgelya to substances of different molecular weight.
Enterosgel characterized by the apparent selectivity: most actively sorbing srednemolekulyarnye toxic metabolites, the end products of metabolism with molecular weights from 70 to 1000 and. f. (urea, bilirubin, cholesterol, srednemolekulyarnye peptides). It almost does not bind substances with molecular weight less than 60-70 (metal ions, mineral salts, electrolytes). Substances with a molecular weight of more than 10,000 au (immunoglobulins, proteins) bind enterosgelem also not be subjected to.

Enterosgelya surface in comparison with other sorbents possess exceptional hydrophobicity. This property is achieved through redundancy of methyl radicals on the surface of Globul Enterosgelya. As the results of microbiological studies of pathogenic and conditionally pathogenic microflora adgeziruetsya to the surface Enterosgelya and destroyed, while nonpathogenic microflora is not exposed to the adhesion and is not destroyed. Components of the dead pathogenic and conditionally - pathogenic bacteria, including fragments of the walls remain on the surface enterosorbent.